Patricia loopman obituary5/16/2023 ![]() ![]() Variables that were significantly associated with VAI were EVD replacement (OR 10, p = 0.001), bilateral EVDs (OR 9.2, p = 0.009), duration of EVD placement (OR 1.1, p = 0.011), increased CSF output/day (OR 1.0, p = 0.001), CSF leak (OR 12.9, p = 0.001), and increased length of hospital stay (OR 1.1, p = 0.002). The authors performed a retrospective chart review of consecutive patients who underwent EVD placement between January 2012 and January 2018.Ī total of 389 patients were included in the study. The aim of this retrospective, single-center large series was to assess the rate and independent predictors of ventriculostomy-associated infection (VAI). Factors predictive of infection reported in the literature are not conclusive. ![]() While this procedure is simple and effective, infection is a major limiting factor. Future studies are needed to compare CSF parameters in aSAH patients with and without bacterial meningitis or ventriculitis.Įxternal ventricular drain (EVD) placement is a common neurosurgical procedure. ![]() The limits we found for the inflammatory reaction in aSAH patients may help physicians to interpret CSF parameters in aSAH patients with an external CSF drain. The estimated median protein concentration decreased from 3.3 g/L (95%CI:2.5–4.2) on day 0 to 1.0 g/L (95%CI:0.8–1.2) on day 14. Estimated mean glucose concentrations remained within the normal range. Highest estimated median leukocyte count was 305 (95%CI:225–412) x10^6/L, and the lowest estimated median erythrocyte/leukocyte ratio was 109 (95%CI:73–163). We included 209 patients with 306 CSF samples. We calculated estimated marginal means with 95% confidence intervals (CIs) with linear mixed models for CSF cell counts, glucose- and protein concentrations. CSF samples were excluded if the patient used antibiotics or if the CSF culture was positive. Patients with aSAH admitted between 20 with at least one CSF sample ≤ 20 days after ictus were included from a prospectively collected database. Such knowledge may help to interpret CSF parameters in patients with an external drain if nosocomial bacterial meningitis or ventriculitis is suspected. We determined CSF cell counts, erythrocyte/leukocyte ratio, and glucose- and protein concentrations in patients ≤20 days after aSAH without bacterial meningitis. Aneurysmal subarachnoid hemorrhage (aSAH) patients have an inflammatory response in the cerebrospinal fluid (CSF). ![]()
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